The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons
نویسندگان
چکیده
منابع مشابه
Docking Based De novo Design of Few Tolcapone Derivatives as Catechol-o- Methyl Transferase (Comt) Inhibitors
Catechol-O-methyl tranferase (COMT; E.C.2.1.1.6) is widely distributed enzyme in nature that plays an essential role in the metabolism of catechol neurotransmitters and catechol linked foreign entities. As L-DOPA, a key medicine in Parkinsonism is being catabolised by COMT, this justified the interest in developing improved COMT inhibitors as significant adjunct to L-DOPA therapy. Although tolc...
متن کاملCatechol-O-methyl transferase and schizophrenia.
Catechol-O-methyl transferase (COMT) is an enzyme involved in the degradation of dopamine. The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT enzyme activity. It is particularely important in prefrontal cortex, since COMT activity is the most important regulator of the prefrontal dopamine function. Gi...
متن کاملassociation of catechol-o-methyl transferase gene polymorphism with prostate cancer and benign prostatic hyperplasia
background : a single nucleotide variation within atechol-o-methyl transferase (comt) gene may alter the comt enzyme activity level. polymorphism of val158met in the comt gene has been related to malignancy. in this regard, a study was carried out to find a possible association between the comt gene polymorphism in patients with sporadic prostate cancer (pca) and benign prostatic hyperplasia (...
متن کاملSystematic mutation analysis of the catechol O-methyltransferase gene as a candidate gene for schizophrenia.
OBJECTIVE Catechol O-methyltransferase (COMT) is involved in the degradation of catecholamine neurotransmitters. Recent linkage studies of schizophrenia and molecular studies of velocardiofacial syndrome suggest that the COMT gene might be a candidate gene for schizophrenia. METHOD The authors systematically searched for mutations and microdeletion of the COMT gene in 177 Chinese schizophreni...
متن کاملMethionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity.
Catechol-O-methyl transferase (COMT) plays a key role in the degradation of brain dopamine (DA). Specifically, low COMT activity results in higher DA levels in the prefrontal cortex (PFC), thereby reducing the vulnerability for attentional and cognitive deficits in both psychotic and healthy individuals. COMT activity is markedly reduced by a non-synonymous single-nucleotide polymorphism (SNP) ...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2006
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4001808